Cracking the Code of Headaches: Insights from Neuroscience

Headaches are a common and often debilitating symptom that can arise from various underlying causes, including neurological, vascular, and psychological factors. Having focused on the neuroscience of headaches with our comprehensive examination, our team of experts at BrainHub explore the potential neural mechanisms involved in headache pathophysiology and pain processing. Our interdisciplinary team of experts have gained insights into the role of neurotransmitters, cortical spreading depression, and trigeminal nerve activation in migraine, tension-type headache, and cluster headache disorders. Here are some research evidence on the above:

1. Hashemi A, Nami M, Oghabian MA, Ganjgahi H, Vahabi Z, Sikaroodi H. Etiopathophysiological assessment of cases with chronic daily headache: A functional magnetic resonance imaging included investigation. Iranian Journal of Neurology. 2012;11(4):127.
2. Modares-Haghighi P, Boostani R, Nami M, Sanei S. Quantification of pain severity using EEG-based functional connectivity. Biomedical Signal Processing and Control. 2021 Aug 1;69:102840.
3. Yuan H, Silberstein SD. Vagus nerve stimulation and headache. Headache: The Journal of Head and Face Pain. 2017 Apr;57:29-33.
4. Chou DE, Gross GJ, Casadei CH, Yugrakh MS. External trigeminal nerve stimulation for the acute treatment of migraine: open-label trial on safety and efficacy. Neuromodulation: Technology at the Neural Interface. 2017 Oct 1;20(7):678-83.
5. Przeklasa-Muszyńska A, Skrzypiec K, Kocot-Kępska M, Dobrogowski J, Wiatr M, Mika J. Non-invasive transcutaneous Supraorbital Neurostimulation (tSNS) using Cefaly® device in prevention of primary headaches. Neurologia i neurochirurgia polska. 2017;51(2):127-34.